Innate Immunity in Disease
نویسندگان
چکیده
منابع مشابه
Innate Immunity and Cardiometabolic Disease
Innate Immunity and Cardiometabolic Disease Innate immunity, an ancient form of host defense, is the body’s rapid, first-line response to environmental threats, such as microbial infection. In contrast to the adaptive immune system—which is present only in higher-order vertebrates, and mediated primarily by somatically generated receptors—the innate immune system relies inherently on basic dete...
متن کاملInnate immunity in alcoholic liver disease
Bin Gao, Ekihiro Seki, David A. Brenner, Scott Friedman, Jessica I. Cohen, Laura Nagy, Gyongyi Szabo, and Samir Zakhari Laboratory of Liver Diseases and Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland; University of California San Diego, School of Medicine, San Diego, California; Division of Liver D...
متن کاملImpaired innate immunity in Crohn's disease.
The aetiology of Crohn's disease--a chronic intestinal disorder that involves an immune response against the commensal bacterial flora--remains fiercely debated. Two hypotheses exist: (i) those who think that the disease is caused by genetic defects that produce exaggerated innate responses to the flora, leading to excessive inflammation; and (ii) those who think that the genetic defects cause ...
متن کاملInnate lymphoid cells in immunity and disease.
The family of innate lymphoid cells (ILCs) comprises of natural killer (NK) cells, Rorγt-dependent ILCs (lymphoid tissue inducer (LTi) cells, ILC22, and ILC17), and type 2 ILCs. Apart from a common requirement for inhibitor of DNA binding 2 (Id2) expression and common γ-chain (γc) signaling, the differentiation of ILC populations is regulated by distinct transcription factors. ILCs play fundame...
متن کاملInnate Immunity in Alcohol Liver Disease
Excessive ingestion of alcohol is one of the major causes of chronic liver disease worldwide. Alcoholic liver disease (ALD) encompasses a broad spectrum of diseases ranging from steatosis (fatty liver), steatohepatitis, fibrosis, cirrhosis to hepatocarcinoma. Almost all heavy drinkers develop fatty liver; however, only up to 30% of heavy drinkers may develop more several forms of chronic liver ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Gastroenterology and Hepatology
سال: 2014
ISSN: 1542-3565
DOI: 10.1016/j.cgh.2014.03.007